<—- Can everyone please remember that yanking bolts and arrows out of your arms -s a great way to d-e from bloodloss? —->


<—- Wow, - have not been on th-s…th-ng -n a wh-le. - blame hav-ng to ass-st my mo-ra-l w-th th-ngs. Not that - m-nded all that much, pardon. —->

<—- R-ght, left that “ask box” open should someone des-re some proper med-cal adv-ce. Doubtless some hapless soul w-ll need me. As usual. —->



madladyrandom submitted:

Today I was pondering the wide variety of unpleasant sensations I’m experiencing in my right arm due to shingles. Not too surprising, since the reactivated varicella-zoster virus is actually messing around in my neurons. Then it struck me—having shingles really gets…

<—- Go-ng to try some new research. —->

<—- Mostly -nvolv-ng….well -‘m sure no one who reads th-s would understand -t, but - w-ll be gett-ng Nurse to ass-st me -n -t. —->


That protein, STIM1, was previously known to sense a change in calcium within immune cells, a process that occurs when the body confronts a pathogen. Upon sensing this change, STIM1 opens a type of pore in the cell membrane, called a CRAC channel, to allow the flow of calcium ions — a vital step in activating the immune system.

“People have generally thought that selectivity of ion channels is fixed and that selectivity and opening are separate processes; this is a fundamental shift in the way scientists believe ion channels operate,” says Prakriya, referring to the ‘pores’ that STIM1 regulates. “CRAC channels and STIM1 are absolutely vital to activating the immune system. As is observed in some human patients, you can block key parts of the system by blocking these molecules in . These finding reveal not only a novel mechanism by which CRAC channels operate, but also new ways in which it encodes biological information. This represents exciting new possibilities to develop therapeutics to treat a broad range of conditions.”


Genomics and Stem Cell Research Give Patient Her Life Back

At 28, Sandra Dillon was the picture of healthy living. She ran every day, ate healthy, didn’t smoke and recycled. But she had been bothered by a bump under her rib cage and after numerous tests, her doctors came back with very bad news: she had myelofibrosis, a life-threatening blood disorder that can lead to acute leukemia. No cure existed and no match for a bone marrow transplant was found. The only course of treatment was to try to manage her symptoms as she got sicker. Basically, there wasn’t much hope.

That was eight years ago. Flash forward to last week when Dillon spoke at the CIRM Governing Board’s Spotlight on Disease seminar to happily report a more hopeful prognosis now that she’s participating in a clinical trial that targets cancer stem cells.

Dillon’s story provides a glimpse into a future of personalized medicine in which genomics, the study of genes and their function, is applied to pinpoint specific treatments for patients. Catriona Jamieson, Sandra’s physician and director for stem cell research at the UCSD Moores Cancer Center, spoke about the research, funded in part by CIRM, which led to the clinical trial.

<—- More about stem cells. Maybe - should try th-s out… —->

<—- Nobody l-stens. —->

<—- Stup-d tealblood wouldn’t l-sten when - warned her about that crash! Th-s -s why - should force my pract-ce. So trolls stop be-ng so stup-d. —->

Every kid starts out as a natural-born scientist, and then we beat it out of them. A few trickle through the system with their wonder and enthusiasm for science intact.
Carl Sagan (via noneofyourbismuth)

<—- Note to self: Do not get b-tten by so called “Brown recluse” sp-derbeast. —->

<—- Talked to a brownblood ton-ght. —->

<—- She seemed n-ce enough. The fnords were we-rd. She really should have gone w-th my suggest-on of surgery, but noooooo, she dec-ded to start be-ng all sad. Pat-ents. —->